Ashutosh Mangalam is a researcher working to develop better treatment options to cure multiple sclerosis (MS).
The ultimate action-packed science and technology magazine bursting with exciting information about the universeEngaging articles, amazing illustrations & exclusive interviewsFatty layers of tissue, called myelin sheaths, insulate the wires of neurons, but these sheaths are damaged in multiple sclerosis.
The environment plays a key role in determining who develops multiple sclerosis, and this is evident from twin studies. Among identical twins who share 100% of their genes, one twin has aof developing MS if the other twin has the disease. For fraternal twins who share 50% of their genes, this rate drops to around 2%.approach: starting with samples from patients with multiple sclerosis, conducting lab experiments on these samples, then confirming our findings in patients.First, we analyzed the chemical and bacterial gut composition of patients with multiple sclerosis, confirming that they had gut inflammation andGet the world’s most fascinating discoveries delivered straight to your inbox.Receive email from us on behalf of our trusted partners or sponsors, was critical in distinguishing mice with or without multiple sclerosis-like disease. Mice with multiple sclerosis-like symptoms had increased levels of. This suggested that an imbalance between these two bacteria might not just be a sign of disease, but could actually. This imbalance was not only linked to having multiple sclerosis but also with worse disability, making it a stronger predictor of disease severity than any single type of bacteria alone.One of the most interesting findings from our study was that normally beneficial bacteria can turn harmful in multiple sclerosis.is usually considered a helpful bacterium, but it became problematic in patients with multiple sclerosis.ratio. In that study, mice fed a diet rich in phytoestrogens — chemicals structurally similar to human estrogen that need to be broken down by bacteria for beneficial health effects — developed milder disease than those on a diet without phytoestrogens. Previously we have shown that people with multiple sclerosis lack gut bacteria that can metabolize phytoestrogen.overconsumes mucin and weakens the gut lining. This process can trigger more inflammation and potentially contribute to the progression of multiple sclerosis.ratio may be a key marker for multiple sclerosis severity could help improve diagnosis and treatment. It also highlights how losing beneficial gut bacteria can allow other gut bacteria to become harmful, though it is unclear whether changing levels of certain microbes can affect multiple sclerosis. While more research can help clarify the link between the gut microbiome and multiple sclerosis, these findings offer a promising new direction for understanding and treating this disease. Ashutosh Mangalam is a researcher working to develop better treatment options to cure multiple sclerosis .'Einstein's equations need to be refined': Tweaks to general relativity could finally explain what lies at the heart of a black hole
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