Certain types of gut bacteria can hinder the efficacy of the rotavirus vaccine, according to researchers.
Certain types of gut bacteria can hinder the efficacy of the rotavirus vaccine, according to researchers in the Institute for Biomedical Sciences at Georgia State University.indicate that gut microbiota, particularly the trillions of bacteria that live in an individual's gut, can influence rotavirus vaccine responsiveness and sometimes result in children remaining prone to rotavirus infection and severe disease despite having been vaccinated.
Rotavirus vaccines are orally administered, live, attenuated viruses that must infect their host's intestine to elicit protective immunity. The protection provided by rotavirus vaccines is highly dissimilar among individuals leading the researchers to hypothesize that the composition of gut microbiota, amidst which the viral vaccine must infect, influence rotavirus vaccine efficacy.
Additional authors of the study include Yanling Wang, Yadong Wang and Jun Zou of the Institute for Biomedical Sciences at Georgia State; Zhenda Shi of the Institute for Biomedical Sciences at Georgia State, Cherokee Federal and the Centers for Disease Control and Prevention; Robert Britton and Sasirekha Ramani of the Baylor College of Medicine; and Baoming Jiang of the Centers for Disease Control and Prevention.Vu L.
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