Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission - Malaria Journal

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Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission - Malaria Journal
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A study published in the MalariaJournal finds that humans aged 6–15 years are the most important demographic group contributing to human-to-mosquito malaria transmission. Malaria control and prevention programmes should target school-age children.

), and an R script that compared the genotype of each locus in a genetic profile to its corresponding locus in other genetic profiles. The similarity of the two genetic profiles was expressed as the proportion of identical alleles at all loci times 100. For example, 19 random loci with identical genotypes divided by 24 total loci multiplied by 100 returns a 79% profile similarity. For mosquitoes whose blood meals originated from the same person, the profile similarity would be 100%.

Genetic profiles of blood meals were also compared to genetic profiles of individual humans. Because a sex-specific marker was included in the genotyping process, the sex of the source of all human blood meals could be determined without the need to match the blood meal profiles to those of the study participants. However, the age of the source of human blood meals could only be determined for blood meals that matched study participants.

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