A research team has recently made a significant advancement in spinal cord injury treatment by using genetically modified human neural stem cells (hNSCs). They found that specifically modulating a gene expression to a certain level in hNSCs can effectively promote the reconstruction of damaged neural circuits and restore locomotor functions, offering great potential for new therapeutic opportunities for patients with spinal cord injury.
A research team co-led by City University of Hong Kong and The University of Hong Kong has recently made a significant advancement in spinal cord injury treatment by using genetically modified human neural stem cells .
"Currently, there are no effective clinical management or treatment regimens for patients with spinal cord injury, often leaving them with lifelong disabilities," explained Professor Jessica Liu Aijia, Assistant Professor in the Department of Neuroscience at CityU and the co-leader of the research.
The genetically modified hNSCs expressing half-dose of SOX9 resulted in robust neuronal differentiation and maturation after transplantation in a hostile microenvironment, promoting neural circuits reconstruction in the spinal cord within a shorter period of time. It also remarkably reduced glial scar accumulation, facilitating long-distance axon outgrowth.
Compared to rats' graft with non-modified hNSCs, rats' graft with SOX9 gene-modified hNSCs performed much better in placing their affected hind paws on the grid, with fewer misdirected steps after 10 weeks post-injury. In addition, these treated rats demonstrated a good gait with clear paw position and toe movement when walking across a metre-long narrow corridor.
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