Researchers at Leiden University Medical Center have developed a novel malaria vaccine delivery method using genetically modified mosquitoes. The study found that mosquitoes infected with modified malaria parasites could effectively vaccinate humans against the disease, providing significant protection against infection.
Researchers at Leiden University Medical Center, backed by the Bill & Melinda Gates Foundation, have developed a new method of delivering malaria vaccines using genetically modified mosquitoes as “flying vaccinators.”, scientists have demonstrated the effectiveness of using mosquitoes as “flying syringes” to vaccinate humans against malaria.
In the trial, 43 adults between the ages of 19 and 35 with no prior history of malaria infection were divided into three groups. The first group received 50 bites from mosquitoes infected with the GA2 parasite, the second group received 50 bites from mosquitoes infected with the GA1 parasite, and the third group, serving as a placebo, received 50 bites from uninfected mosquitoes. The participants underwent three vaccination sessions at 28-day intervals.
Three weeks after the final vaccination session, the human test subjects were exposed to malaria infection through bites from infected mosquitoes. The results showed that eight out of nine participants in the GA2 group were effectively protected against malaria, while only one out of eight in the GA1 group and none in the placebo group received protection.
The concept of using mosquitoes as “flying vaccinators” has been explored by scientists for years. In 2010, Japanese researcher Shigeto Yoshida modified mosquito saliva to deliver leishmania vaccines to mice, noting that vaccination by insect could be painless and cost-effective. However, concerns about informed consent and medical safety have hindered the development of this approach. That doesn’t appear to be a concern for Bill Gates and the professors he is funding today.
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