A higher cumulative genetic burden for depression is linked to an increased risk for relapse and worsening disability in people with MS, early results of a new study showed.
is associated with an increased risk for relapse and worsening disability in people with multiple sclerosis , early results of a new study showed.
Depression is a common comorbidity in patients with MS and is associated with increased relapse and disability progression. Depression risk is partly polygenic in nature, involving numerous common genetic variants, said Kowalec. The median baseline Expanded Disability Status Scale score was higher in the Canadian cohort than in the Swedish and US cohorts,"reflective of the Canadian cohort being slightly more progressed," said Kowalec.To measure depression heritability, researchers generated a polygenic risk score in whole-genome imputed genotypes. The score reflects the number of inherited common genetic variants, weighted by effect sizes.
She noted the Canadian cohort did not have many relapses, while the US and Swedish cohorts"had an increased rate." Asked by a delegate if confounding by a third variable is possible, Kowalec said because genetic markers don't change over time, there is a hint that the direction is causal and that depression is driving the outcome. However, she added, further confirmation is needed.
Genetics Canada Canadian Disability Genetic Testing Genomics Genomic Medicine Europe European Multiple Sclerosis Multiple Sclerosis MS - Multiple Sclerosis Antidepressant Antidepressant Drug Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Birth Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial
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