Research indicates that genetic predisposition supersedes age as a risk factor in adults above 65. According to a recent study, once individuals reach the age of 65, which is the threshold for the onset of Alzheimer's disease, their genetic risk may play a larger role in determining if they will de
Alzheimer’s disease, a progressive neurological disorder, is the most common form of dementia affecting millions of people worldwide. This devastating condition erodes memory, cognitive abilities, and eventually the ability to perform daily tasks. Although primarily associated with aging, Alzheimer’s has a complex interplay of genetic, environmental, and lifestyle factors.
“We all know Alzheimer’s disease is a later-onset disease, so we know age is an important risk factor. But when we consider risk only for people age 65 or older, then genetic information captured by a polygenic risk score ranks higher than age,” said lead study author Xiaoyi Raymond Gao, associate professor of ophthalmology and visual sciences and of biomedical informatics in The. “That means it’s really important to consider genetic information when we work on Alzheimer’s disease.
Of the 457,936 UK Biobank participants in the sample, 2,177 individuals had developed Alzheimer’s disease and 455,759 had not, and 88,309 were 65 or older. “Machine learning can explore relationships among all of those features, or variables, pick the important features and rank certain features at the top that contribute much more to Alzheimer’s disease risk than the rest of the features,” Gao said. “Typically, it’s not good to be highly obese, but we also see here that a lower body mass index is not good. High blood pressure is typically not good, but here we see lower diastolic blood pressure is not good.
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