Smokers with extreme phenotypes of high and low risk of developing tobacco-associated lungcancer have different genetic profiles, according to a multidisciplinary study.
Manage Email AlertsMADRID — Smokers with extreme phenotypes of high and low risk of developing tobacco-associated lung cancer have different genetic profiles, according toconducted by specialists from the Cancer Center at the University of Navarra Clinic . The results were presented at the last meeting of the American Society for Clinical Oncology held in Chicago, United States.
The study was conducted using DNA from 133 heavy smokers who had not developed lung cancer at a mean age of 80 years, and from another 116 heavy smokers who had developed this type of cancer at a mean age of 50 years. This DNA was sequenced using next-generation techniques, and the results were analyzed using bioinformatics and artificial intelligence systems in collaboration with the University of Navarra Applied Medical Research Center and the University of Navarra School of Engineering.
"Many genetic variants that we have identified as differentials in cases and controls are found in genes relevant to the immune system , in genes related to functional pathways that are often altered in tumor development, and in structural proteins and in genes related to cell mobility," emphasized Patiño.
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