Increased BMI contributed to a higher risk for PCOS, and conversely, the severity of PCOS affected the BMI in an analysis of genome-wide association data.
To explore causality between BMI and PCOS , researchers used a bidirectional, two-sample Mendelian randomization approach with genome-wide association studies summary data from two large independent European populations: The UK Biobank for BMI and the FinnGen biobank for PCOS .
They applied three analytical methods: Inverse-variance weighted method, weighted median estimator, and MR-Egger regression.Researchers found a positive association between increased BMI and a higher risk for PCOS across all methods used (IVW: odds ratio , 2.027; weighted median estimator: OR, 2.368; MR-Egger regression: OR, 3.610;"The findings highlight the importance of recognizing and safeguarding populations at risk of PCOS due to overweight or obesity," the authors wrote.
Obese Body Mass Index BMI Genomics Genomic Medicine Genetics Female Infertility Endocrinology Endocrine System Fertility Hospitals Metabolism Metabolic Polycystic Ovary Syndrome Polycystic Ovarian Disease Polycystic Ovarian Syndrome PCOS Stein-Leventhal Syndrome UK Site Content United Kingdom Site Content United Kingdom UK
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