Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, according to a new article.
Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, a new paper has found.discovered that a gene deficiency found in patients with atrial fibrillation may be leading to reduced energy production in heart cells. Deficiencies in the PITX2 gene in heart cells leads to some mitochondria, which are parts of the cell that produce energy, being smaller and less efficient.
Gene Expression: Analysis of the genes in these cells reveals significant differences in those involved in energy production and ion channel function . Similar changes are observed in the heart tissue of patients with AF compared to those with normal heart rhythms. "We observed that the deficiencies in the PITX2 gene leads to heart cells not functioning properly, including having a smaller and less efficient system for producing energy. This means that those heart cells are having to increasingly rely on glycolysis to produce energy which introduces oxygen stress into the mix.
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