Gene-edited calf may reduce reliance on antimicrobials against cattle disease unlnews PNASNexus
The bovine viral diarrhea virus devastates the bovine immune system and can cause severe respiratory and intestinal harm to infected beef and dairy cattle, said veterinary epidemiologist Brian Vander Ley, an associate professor in the University of Nebraska-Lincoln's School of Veterinary Medicine and Biomedical Sciences.
The cattle industry has vaccinated against the disease since the 1960s, but"the highly mutable nature of BVDV and the emergence of highly virulent strains of BVDV contribute to limited success of present control programs," the Academy of Veterinary Consultants has stated. "Our objective was to use gene-editing technology to slightly alter CD46 so it wouldn't bind the virus yet would retain all its normal bovine functions," said Aspen Workman, a scientist with the ARS U.S. Meat Animal Research Center in Clay Center, Nebraska.
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