For adults with refractory or unexplained chronic cough, gefapixant leads to modest improvement in cough frequency, severity, and quality of life, according to a review published online Sept. 11 in the Journal of the American Medical Association to coincide with the European Respiratory Society International Congress 2023, held from Sept. 9 to 13 in Milan.
that compared gefapixant with placebo or two or more doses of gefapixant with or without placebo. The primary analysis included nine RCTs with 2,980 patients.
The researchers found that gefapixant had small effects on awake cough frequency , cough severity , and cough-specific compared with placebo. However, an important increase in treatment-related adverse events and taste-related adverse events was probably caused by gefapixant versus placebo. Small effects on taste-related adverse events were suggested for gefapixant versus placebo based on high-certainty evidence.
"Although gefapixant did appear to have a small effect on improving cough compared with placebo, the effects were marginal when compared with the large, favorable effects of alone," Richard S. Irwin, M.D., and J. Mark Madison, M.D., from the University of Massachusetts Chan Medical School in Worcester, write in an accompanying editorial.More information:
Elena Kum et al, Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough,
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