A new study has found that slower gait speed is independently associated with an increased risk of cardiovascular death or worsening heart failure in patients with stable heart failure. However, measures of muscle strength and mass, such as handgrip strength and appendicular skeletal muscle index, were not linked to changes in outcomes.
Slower gait speed is independently associated with an increased risk for cardiovascular death or worsening heart failure in patients with stable heart failure with reduced or improved left ventricular ejection fraction, whereas parameters of muscle strength and mass such as handgrip strength and appendicular skeletal muscle index were not linked to changes in outcomes.
They conducted a prospective cohort study of 205 adult patients with stable chronic heart failure who were previously diagnosed with overtly reduced left ventricular ejection fraction below 40% and LVEF below 50% at enrollment. Gait speed was measured in m/s, maximal handgrip strength was assessed in kg, and appendicular skeletal muscle index was measured in kg/mLow physical performance was defined as having a gait speed of 0.8 m/s of slower, low muscle strength as having maximal handgrip strength below 27 kg for men and less than 16 kg for women, and low muscle mass as having an appendicular skeletal muscle index below 7.
The associations remained consistent across key clinical subgroups stratified by gender, comorbidities, and organ function biomarkers.“A differentiated analysis of multiple muscle parameters within a single cohort can provide useful evidence to identify which are clinically most important,” the authors of the study wrote.
CARDIOVASCULAR HEALTH HEART FAILURE GAIT SPEED MUSCLE STRENGTH PHYSICAL PERFORMANCE
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