A new study comparing gabapentin and duloxetine users found that gabapentin users experienced significantly fewer fall-related healthcare visits. Researchers analyzed data from over 57,000 adults aged 65 and older with conditions like postherpetic neuralgia, diabetic neuropathy, or fibromyalgia. Incident gabapentin use was associated with a 48% lower hazard of falls at a 6-month follow-up.
Among 57,086 older adults , new gabapentin users demonstrated lower fall-related healthcare visits than duloxetine users, with a weighted cumulative incidence of 84.44 vs 158.21 per 1000 person-years at 180 days. Incident gabapentin use showed a 48% lower hazard of falls at 6-month follow-up, with no increase in severe fall-related events.Researchers conducted a new user, active comparator cohort study using IBM MarketScan Research Databases from January 2014 to December 2021.
Analysis included 57,086 adults aged ≥ 65 years with postherpetic neuralgia, diabetic neuropathy, or fibromyalgia, excluding those with depression, anxiety, seizures, or cancer in the prior 365 days. The primary outcome measured the hazard of experiencing any fall-related visit in the 6 months after initiating gabapentin or duloxetine until treatment discontinuation.The analytic cohort included 52,152 gabapentin users and 4934 duloxetine users, with a median follow-up duration of 30 days .
Weighted cumulative incidence of fall-related visits per 1000 person-years at 30, 90, and 180 days was 103.60, 90.44, and 84.44 for gabapentin users vs 203.43, 177.73, and 158.21 for duloxetine users. At 6-month follow-up, incident gabapentin users demonstrated lower hazard of falls , with no difference in hazards of severe falls."One bioplausible explanation for our results is that gabapentin is a highly titratable medication and many in our cohort started on low doses. Alternatively, duloxetine is usually titrated only once or twice.
Gabapentin Duloxetine Falls Older Adults Healthcare Visits
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