A sizeable proportion of patients with cancer who experience cognitive decline after radiation treatment for brain metastases may regain full neurocognitive function within 6 months.
Barring full cognitive recovery, roughly three quarters of patients showed improvement on at least one cognitive test, even if they initially failed that test after radiation, according to research presented at theThe findings underscore that neurocognitive decline after brain radiation is"not necessarily permanent," lead researcher Hua-Ren Cherng, MD, with University of Maryland Medical Center, Baltimore, said during a presentation at the meeting.
live longer," Stephanie E. Weiss, MD, chief of the Division of Neurologic Oncology, Fox Chase Cancer Center, Philadelphia, who wasn't involved in the study, toldAbout 200,000 patients with cancer are diagnosed with brain metastases annually in the US. Neurocognitive changes following brain radiation therapy remain significant concerns for these patients, especially those receiving whole-brain radiation therapy .
Cognitive outcomes were the primary endpoint in all three trials. Two of the trials compared WBRT vs stereotactic radiosurgery, and the third compared standard WBRT vs hippocampal-avoidance WBRT. Of the 288 patients with cognitive decline after brain radiation, 38% fully recovered by 6 months and 42% by 12 months. Among a subset of patients who continuedNearly 80% of patients showed improvement on at least one previously failed cognitive test, Cherng noted.
There was a trend toward a significant increase in the cumulative incidence of full cognitive recovery with hippocampal-avoidance WBRT vs WBRT . Age, histology, and performance status were not significant predictors of cognitive recovery. Offering perspective on the study, Lia Halasz, MD, chair of the ASTRO CNS Resource Panel, said one of the"truly gratifying" parts of her career has been seeing patients with brain metastases live longer over time.
Head And Neck Cancer Head And Neck Cancer (HNC) Brain Metastasis Metastatic Brain Tumor Metastatic Disease To The Brain Brain Metastases Metastatic Brain Tumour Brain Brain Cancer Malignant Brain Neoplasm Metastasis Metastatic Carcinoma Metastatic Cancer Metastases Biologic Therapy Biologics Radiation Therapy Radiotherapy Radiation Oncology
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