Frequent Colorectal Polyp Diagnoses in Relatives Linked to Increased Risk for Colorectal Cancer

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Frequent Colorectal Polyp Diagnoses in Relatives Linked to Increased Risk for Colorectal Cancer
Colorectal Cancer (CRC)PolypCancer
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The risk for colorectal cancer was associated with the frequency of colorectal polyp diagnoses in relatives in a study based on family cancer datasets.

Frequent colorectal polyp diagnoses in first- and second-degree relatives are associated with an increased risk for colorectal cancer , especially early-onset CRC.Researchers evaluated the association between the frequency of colorectal polyp diagnoses in relatives and the risk for overall and early-onset CRC using data from four Swedish family cancer datasets .

In total, 11,676,043 individuals born after 1931 with at least one known first-degree relative were included; the median follow-up duration was 31 years. Individuals with one first-degree relative with frequent polyp diagnoses had a 2.27-fold increased risk for early-onset CRC and a 1.82-fold increased risk for overall CRC .

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