Eleven other people have recovered from the disease which has killed more than 2,600 people worldwide and infected almost 80,000 others, mainly in China.
One of the four people still being treated in hospital, a 55-year-old man, is listed in critical condition in the northern city of Amiens.
Two of the four had recently returned from the Lombardy region of Italy, which is at the centre of Europe's biggest outbreak of the disease with 10 dead. The French government has asked citizens returning from Lombardy and the neighbouring Veneto region to avoid"all non-essential outings" and keep their children home from school.
The same recommendations have been issued from people returning from mainland China, Hong Kong, Macau, Singapore and South Korea.
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