What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes.
Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
The researchers fed hungry mice that could only see and smell the food without eating it. After just a few minutes, the researchers analysed the mitochondria in the liver and found that processes normally stimulated by food intake were activated.The studies show that it is sufficient for the mice to see and smell food for a few minutes to influence the mitochondria in the liver cells. This is mediated by a previously uncharacterised phosphorylation in a mitochondrial protein.
Jens Brüning is also a research group leader at the CECAD Cluster of Excellence in Ageing Research at the University of Cologne and Director of the Department of Endocrinology, Diabetology and Preventive Medicine at Cologne University Hospital.Sinika Henschke, Hendrik Nolte, Judith Magoley, Tatjana Kleele, Claus Brandt, A. Christine Hausen, Claudia M. Wunderlich, Corinna A. Bauder, Philipp Aschauer, Suliana Manley, Thomas Langer, F. Thomas Wunderlich, Jens C. Brüning.
Diabetes Nervous System Nutrition Molecular Biology Cell Biology Food Biology
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