Phase I clinical trial of a drug was successfully completed, with promise to treat Alzheimer's and other neurodegenerative diseases. The compound, named VU319, is the first end-to-end drug discovery effort related to memory loss, starting from the earliest basic science research through human clinical trials.
Phase I clinical trial of a drug was successfully completed, with promise to treat Alzheimer's and other neurodegenerative diseases. The compound, named VU319, is the first end-to-end drug discovery effort related to memory loss, starting from the earliest basic science research through human clinical trials.
John Kuriyan, dean of basic sciences and University Distinguished Professor of Biochemistry and Chemistry, agreed, adding,"The successful phase I trial of VU319 marks a potentially transformative step in drug development for Alzheimer's, showcasing Vanderbilt's capacity to translate fundamental research into therapeutic discovery that brings the hope of real clinical impact."
In addition to treating Alzheimer's disease, which affects roughly 6.9 million people over age 65 and has no known cure, VU319 has shown potential to treat memory loss in schizophrenia, prion diseases, Rett syndrome, vascular dementia, and Lewey body dementia. In the human trial performed at Vanderbilt by Dr. Paul Newhouse, professor of psychiatry and pharmacology, director of the Vanderbilt Center for Cognitive Medicine, and clinical core director of the Vanderbilt Memory and Alzheimer's Center, the researchers saw signs of target engagement at the highest dose of the treatment that was tested and saw no side effects typical of other drugs working on the same area of the brain.Michael S. Poslunsey, Michael R. Wood, Changho Han, Shaun R.
Pharmacology Healthy Aging Mental Health Research Alzheimer's Dementia Mental Health Depression
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