At 1 year, islets chemically reprogrammed from the patient's own somatic cells allowed them to become insulin-independent with the use of immunosuppression.
A new approach to using stem cell –derived pancreatic islets has allowed a patient with type 1 diabetes to come off insulin for 1 year.
Of note, she was already under immunosuppression for a prior liver transplant and remained on it throughout. There were no major safety concerns. Another difference is that"the patient-specific stem cell–derived islets used in this study were produced from induced pluripotent stem cells generated using chemical reprogramming, which is a non-transgenic approach to inducing pluripotent stem cells from somatic cells that uses only small molecules, different from the conventional method of viral transduction of transcription factors…Employing small molecules as reprogramming factors provides a greater degree of control — small molecules...
Moreover, they added,"to our knowledge, the rapidity with which insulin-independence was achieved post-transplantation of stem cell–derived islets, 75 days post-transplantation, is also a first."Asked to comment, David M.
Diabetes Mellitus Type I Type 1 Diabetes Type 1 DM T1DM T1D Transplantation Of Stem Cells Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy Stem Cell Haematopoietic Stem Cell Transplant HSCT Hematopoietic Stem Cell Transplantation (HSCT) Haematopoietic Stem Cell Transplantation (HSCT)
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