An early rejection required treatment, but the patient in the groundbreaking case is reported to be 'doing fine'; longer-term outcomes are being watched.
The transplant team at Massachusetts General Hospital reports that the recipient of the first-ever transplant of a genetically edited porcine kidney into a living human was discharged from the hospital this week, 2 weeks after receiving the groundbreaking operation, and so far is doing well.
In a press statement, the patient, identified as 62-year-old Richard Slayman, of Weymouth, Massachusetts, described the ability to leave the hospital with a clean bill of health as "one of the happiest moments of my life."and had developed end-stage kidney disease after the failure of a previous kidney transplant from a human deceased donor in 2018 at the same center.
The next experiments involved transplanting the engineered kidneys into brain-dead humans. With those also proving successful, the MGH transplant team determined that Slayman was an ideal candidate for the groundbreaking surgery, and they applied for and were granted compassionate use permission from the US Food and Drug Administration .
"We know that's going to require additional engineering, but we're going to need the human data to help inform what the engineering looks like."Transplant surgeon Jayme E. Locke, MD, MPH, who was involved in the earlier porcine kidney transplants in brain-dead patients, says his team is moving ahead with plans to proceed withLocke agrees that hopes are high for a long durability of the porcine donor organ transplant with any of the approaches.
ESRD - End Stage Renal Disease ESRD ESKD End-Stage Kidney Disease (ESKD) ESKD - End Stage Kidney Disease Chronic Renal Failure Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Transplantation Of The Kidney
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Surgeons complete first-ever gene-edited pig kidney transplantMack DeGeurin is a tech reporter who’s spent years investigating where technology and politics collide. His work has previously appeared in Gizmodo, Insider, New York Magazine, and Vice.
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