A small droplet that contains the coronavirus can infect someone with COVID-19, according to results from the first COVID-19 human challenge study, published in Nature Medicine.
Apr. 1, 2022 -- A small droplet that contains the coronavirus can infect someone with COVID-19, according to.
The researchers conducted the trial in phases for safety. The first 10 participants who were infected received remdesivir, the antiviral drug, to reduce their chances of progressing to severe COVID-19. The research team also had monoclonal antibodies on hand in case any volunteers developed more severe symptoms. Ultimately, the researchers said, remdesivir was unnecessary, and they didn’t need to use the antibodies.
About 83% of participants who contracted COVID-19 lost their sense of smell to some degree, and nine people couldn’t smell at all. The symptom improved for most participants within 90 days, though one person still hadn’t fully regained their sense of smell about six months after the study ended.Small amounts of the virus can make someone sick. About 10 microns, or the amount in a single droplet that someone sneezes or coughs, can lead to infection.
COVID-19 has a short incubation period. It takes about two days after infection for someone to begin shedding the virus to others.In addition, infected people can shed high levels of the virus even if they don’t develop any symptoms. The findings emphasize the importance of contagious people covering their mouth and nose when sick to protect others, Chiu told CNN.
Now the research team will conduct another human challenge trial, which will include vaccinated people who will be infected with the Delta variant. The researchers intend to study participants’ immune responses, which could provide valuable insights about new variants and vaccines.
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