In Brief: An EMA_News committee recommends an allogeneic T cell immunotherapy from Atara Biotherapeutics $ATRA for approval. Ebvallo would be the first off-the-shelf treatment to receive a green light
Ebvallo works by targeting and eliminating EBV-infected cells in immunocompromised patients who lack sufficient T cells to combat the virus. The company’s allogeneic platform consists of T cells enriched from whole blood from third-party donors, activated through exposure to certain viral antigens, and stored for later use in a partially human leukocyte antigen -matched patient.
The company expects to leverage this technology to treat other cancers and autoimmune diseases. One of its allogeneic EBV T cell treatments, ATA188, is in a phase 2 study to treat progressive forms of multiple sclerosis. This investigational off-the-shelf immunotherapy has the potential to selectively identify and tackle EBV-infected B and plasma cells in the nervous system that are
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