A noninvasive method showed potential to screen for adherence and reduce clinical burden.
Analysis of finger sweat detected isoniazid in adults with tuberculosis for ≤ 6 hours after administration, based on data from a new pilot study.
Although TB is treatable,"it is well known that insufficient drug dosing leads to treatment failure and drug resistance, and so ensuring that patients are have sufficient drug exposure is important," corresponding author Melanie J. Bailey, PhD, also of the University of Surrey, said in an interview. Overall,"isoniazid and acetyl isoniazid were detected in at least one finger sweat sample from all patients," with detection rates of 96% and 77%, respectively, the researchers wrote. Given the short half-life of isoniazid, they used a window of 1-6 hours after administration. Isoniazid was consistently detected between 1 and 6 hours after administration, while acetyl isoniazid had a noticeably higher detection rate at 6 hours.
In the current study,"I was struck by the correlation between the sweat and serum values of INH and by the level of sophistication of noninvasive testing, being able to normalize for creatinine to account for different volumes of sweat," Thavarajah told. In clinical practice, finger sweat isoniazid could potentially serve as an adjunct or alternative to DOT in patients with TB, she said.
TB - Tuberculosis TB Fingers Adherence Adherence To Medication Issues For Patients Compliance Drug Compliance Treatment Adherence Blood Preventive Screening Screening Interstitial Lung Disease Drug Resistance Hospitals Kidneys Lung Mass Spectrometry Michigan Microbicides Antimicrobials Mobility Student Transplant Evaluation Patient Selection
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