A drug that combines an atypical antipsychotic and an SSRI is under FDA review, and if approved will be the first FDA-approved medication for PTSD in more than 20 years.
A drug that combines the atypical antipsychotic brexpiprazole and the selective serotonin reuptake inhibitor sertraline provides significantly greater relief of posttraumatic stress disorder symptoms than sertraline plus placebo, results of a phase 3 trial showed.
“And what is really cool, what’s really impactful is the combination worked better than sertraline plus placebo on a brief inventory of psychosocial functioning,” study investigator Lori L.
“New medications that might address the important ‘effectiveness gap’ in PTSD could help to reduce the remaining distress, disability, and suicide risk associated with PTSD.” included 416 adults aged 18-65 years with a DSM-5 diagnosis of PTSD and symptoms for at least 6 months prior to screening. Patients underwent a 1-week placebo-run in period followed by randomization to daily oral brexpiprazole 2-3 mg plus sertraline 150 mg or daily sertraline 150 mg plus placebo for 11 weeks.
At the last visit, the mean change in body weight from baseline was an increase of 1.3 kg for brexpiprazole plus sertraline vs 0 kg for sertraline alone. Rates of fatigue and somnolence were also higher with brexpiprazole plus sertraline.“We’ve looked at that data and the sertraline/placebo response was a lot higher, so it was not due to a lack of response with the combination but due to a more robust response with the active control,” Davis said.
Post-Traumatic Stress Disorder Post-Traumatic Stress Syndrome Posttraumatic Stress Disorder Post-Traumatic Stress Disorder (PTSD) U.S. Food And Drug Administration United States Food And Drug Administration FDA Food And Drug Administration (FDA) Food And Drug Administration Atypical Antipsychotics Second Generation Antipsychotics Stress Antipsychotics Neuroleptics
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
New England Patriots Could Take Full Advantage of Jets DownfallThe New England Patriots should monitor a massive trade option with the New York Jets.
Read more »
Tesla Finally Offers Lease Buyout Option, But Do The Math FirstTesla’s lease buyout option, now available for all new models, could benefit those ineligible for federal rebates
Read more »
FDA may finally ban artificial red dye from beverages, candy and other foodsA decision on Red No. 3, the synthetic coloring made from petroleum, could come in the next few weeks.
Read more »
The FDA May Finally Ban This Controversial Food AdditiveA food coloring long banned across Europe — Red No. 3 — is found in many American foods such as cereals, beverages, snacks, and candies. But it may soon be banned nationwide by the FDA. Here's what you need to know.
Read more »
New Tesla Model 3 Long Range Gets Acceleration Boost Option In Some MarketsThe paid upgrade allows owners to enjoy even more thrilling straight-line performance with the comfort of the regular model
Read more »
2026 BYD Dolphin EV Breaks Cover With A Prettier Face And A New Powertrain OptionThe Chinese MIIT gives us an early look at the refreshed version of BYD's entry-level EV
Read more »