Ferritin Cutoff Values Affect Diagnosis of Iron Deficiency

Iron Deficiency Anemia News

Ferritin Cutoff Values Affect Diagnosis of Iron Deficiency
Sideropenic AnemiaIron-Deficiency AnemiaIron Deficiency Anaemia
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As the cutoff value increases, the frequency of diagnosis also increases.

Ferritin is the parameter most often used in primary care to diagnose iron deficiency. The cutoff value of ferritin can affect the number of cases diagnosed, however. A study published inThe study, which included 255,351 adult primary care patients in Switzerland, showed that ferritin cutoff values of 15, 30, and 45 ng/mL were associated with incidences of iron deficiency diagnoses of 10.9, 29.9, and 48.3 cases per 1000 patient-years, respectively.

"It is a study to take into account, especially because of the number of patients it includes, and it can guide primary care clinical practice.

He also pointed out that he does not consider it necessary to raise the cutoff to 45 ng/mL; however,"establishing the cutoff at 30 ng/mL, in a certain population at risk of iron deficiency or iron-deficiency anemia, may be interesting, for example in women of childbearing age, women with very heavy menstruation, children, frail elderly, people with gastrointestinal bleeding, or those who engage in physical exercise.

Iron deficiency must be distinguished from anemia."If the ferritin is below 15 ng/mL, there is iron deficiency, which may or may not be accompanied by symptoms, although usually most patients will have symptoms. Normally, to diagnose a patient with iron-deficiency anemia, on the one hand, they must have low hemoglobin, which indicates anemia, and on the other hand, low ferritin, which indicates iron deficiency." Taking these parameters into account, the study does have a weakness.

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