Although a new placebo-controlled trial failed to show symptom improvement, it yielded some interesting insights that may help in the design of future studies.
is safe but does not offer clinically meaningful improvement in symptoms, results of a new, randomized placebo-controlled trial show.
All patients had whole-bowel lavage starting the day before the colonoscopy. Fecal microbiota transplantation was administered as a single-dose and without antibiotic pretreatment. Secondary outcomes and post hoc analyses showed a greater increase in dopaminergic medication, which may indicate faster disease progression, but also improvement in certain motor and nonmotor outcomes in the placebo group.
The researchers raised the possibility that the placebo procedure was not an inert comparator, given the relatively strong and sustained gut microbiota alteration and dysbiosis conversion observed in the placebo group, and suggested that the colonic cleansing procedure may also have had some beneficial effect.
Parkinson Disease Parkinsons Parkinson Parkinson Disease (PD) Biologic Therapy Biologics C. Diff Infection Clostridium Difficile Infection Clostridium Difficile-Associated Disease C. Diff-Associated Disease Fecal Transplantation Stool Transplant Fecal Bacteriotherapy Fecal Microbiota Transplantation
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