The trial is expected to begin this summer and will enroll 12 individuals under age 18 years.
The US Food and Drug Administration has approved the launch of the first clinical trial for chimeric antigen receptor T-cell therapy in children with
The trial, called Reversing Autoimmunity through Cell Therapy , will take place at Seattle Children's Hospital in Washington state and is expected to begin this summer.. While the FDA has approved a number of clinical trials using CAR-T therapy to treat autoimmune diseases in adults, this is the first authorization for a CAR T-cell therapy trial to treat autoimmune disease in children.
To be eligible for the trial, participants must have failed at least two standard immunosuppressive therapies as well as have evidence of active lupus disease affecting a major organ system, such as the heart, lungs, and kidneys. "Seattle Children's Hospital will be the only site for this study, although patients can travel to Seattle to receive the therapy and then return back to their primary center for ongoing care," Jackson said. All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
SLE - Systemic Lupus Erythematosus Systemic Lupus Erythaematosus SLE Biologic Therapy Biologics Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors
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