Science, Space and Technology News 2024
The ‘gut-germline axis’ is a connection between the gut, its microbiota and the germline. Credit: Joana Carvalho/Isabel Romero Calvo/EMBL
The gut microbiota is a community of microorganisms residing in the gastrointestinal tract. It plays a key role in producing enzymes, metabolites, and other molecules essential for host metabolism and environmental responses. The scientists then analyzed changes in the composition of important testicular metabolites. They found that in male mice dysbiosis affects the physiology of the testes, as well as metabolite composition and hormonal signalling. At least part of this effect was mediated by changes in the levels of the key hormone leptin in the blood and testes of males with induced dysbiosis.
“Our study demonstrates the existence of a channel of communication between the gut microbiota and the reproductive system in mammals. What’s more, environmental factors that disrupt these signals in prospective fathers increase the risk of adverse health in offspring, through altering placental development” said Jamie Hackett, coordinator of the research project and an EMBL Rome Group Leader.
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