In a study of families that have multiple children with autism, researchers have unearthed new insights into genes that might drive the disorder.
The researchers found seven potential genes that are predicted to increase the risk of autism: PLEKHA8, PRR25, FBXL13, VPS54, SLFN5, SNCAIP and TGM1. Most of the new genes were supported by rareThey also examined what is called polygenic risk, in which a combination of commonly found genetic variations can raise the likelihood of developing autism.
Children who inherited rare mutations from unaffected parents in combination with polygenic risk were more likely to have autism, the study showed. The findings help explain why parents who carry a single rare mutation may not show signs of autism even if their children do, according to the study. It also supports the liability threshold model, a concept in behavioral genetics that holds there is an additive effect of genes that influences the probability that someone develops a certain trait.
Children who had a language delay had a higher likelihood of inheriting a polygenic score associated with autism. There was not a similar relationship for children without language delays.
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