Several factors, including treatment type, influenced the likelihood of achieving a pathologic complete response after preoperative chemotherapy and surgery in localized pancreatic adenocarcinoma.
Achieving a pathologic complete response was associated with a twofold higher 5-year overall survival rate among patients with localized pancreatic adenocarcinoma who underwent preoperative chemotherapy and resection, a multicenter cohort study found. Several factors, including treatment type and tumor features, influenced the outcomes.Preoperative chemotherapy is increasingly used in patients with localized pancreatic adenocarcinoma and may improve the chance of a pathologic complete response.
In the current analysis, researchers investigated the incidence and factors associated with pathologic complete response after preoperative chemotherapy among 1758 patients with localized pancreatic adenocarcinoma who underwent resection after two or more cycles of chemotherapy . Factors associated with overall survival and pathologic complete response were investigated with Cox proportional hazards and logistic regression models, respectively.Researchers found that the rate of pathologic complete response was 4.8% in patients who received chemotherapy before pancreatic cancer resection.
Pancreatic Cancer Cancer Of The Pancreas Preoperative Pancreatic Adenocarcinoma Adenocarcinoma Of The Pancreas Breast Cancer Malignant Breast Neoplasm Breast Carcinoma Adenocarcinoma Radiation Therapy Radiotherapy Radiation Oncology Biologic Therapy Biologics Ovarian Cancer Malignant Ovarian Neoplasm Ovary Cancer Cancer Malignant Neoplasia Carcinoma
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