A study published in BMCPediatr finds that the concomitant use of piperacillin-tazobactam did not increase risk of acute kidney injury during vancomycin administration in preterm infants.
Although precedent AKI was excluded from the study population in this study, precedent NEC was associated with AKI, and NEC was common in preterm infants who developed NEC []. In a previous study, half of the participants received ibuprofen, and one out of five infants did so at the time of VCM treatment.
This study has some limitations, including its small sample size and retrospective design. Moreover, the association between AKI and VCM concentration could be underestimated, as there were missing values in the VCM concentration data for 13 patients from the non-AKI group. Also, potential effects of antibiotics other than VCM on the renal function were not fully demonstrated in this study, as relatively small number for patients received each agent.
However, this study showed results consistent with a previous study showing that TZP did not increase the risk of AKI during VCM use [In this study, the concomitant use of TZP did not increase risk of AKI during VCM administration. However, lower GA and antecedent NEC were shown to be associated with AKI in this population.The datasets generated and analyzed are not publicly available but are available from the corresponding author upon reasonable request.
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