The modified common cold viruses behind high-profile COVID-19 vaccine candidates from China's CanSino Biologics and Russia's Gamaleya Institute have been studied for decades, but are still not widely used.
- The modified common cold viruses behind high-profile COVID-19 vaccine candidates from China’s CanSino Biologics and Russia’s Gamaleya Institute have been studied for decades, but are still not widely used.
Graham planned to use them to study mechanisms underlying cancer, and distributed the human kidney cell line that makes them, called HEK293, to researchers all over the world. Some researchers believe the strong immune response that caused problems with gene therapy makes these vectors well suited to vaccines, where much lower doses are used and a protective immune response is the objective.At McMaster University in Canada, Graham and collaborators developed a variety of Ad5 vectors, including for a rabies vaccine used on wild raccoons in the province of Ontario.
The Chinese company’s focus later shifted to an Ad5-based Ebola vaccine at the request of the Chinese military, according to Dr. Thomas Evans, current chief scientific officer at Vaccitech, who was involved with the tuberculosis project. The Ebola vaccine was approved for military use in 2017.
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