Science, Space and Technology News 2024
A recent study emphasizes the necessity of ongoing surveillance of COVID-19 variants and vaccine effectiveness, revealing that monovalent vaccines offer higher antibody levels against Omicron variants than bivalent vaccines. However, current vaccines may not prevent transmission of the newest strains, highlighting the need for continuous vaccine updates and the development of effective antibody treatments.
The team collected blood and nasal mucosal samples both before and after a fifth dose vaccination from 71 participants of the Legacy study, a research collaboration between the Crick and the NIHR University College London Hospitals Biomedical Research Centre. They compared the antibody levels before and after vaccination.
They found that the monovalent vaccine increased their ability to produce mucosal antibodies against most of the tested variants, whereas the bivalent vaccine didn’t provide a significant boost. This highlights the importance of careful vaccine updates and continuing to complement a vaccination program with the development of antibody drugs that work against all variants, as some more vulnerable people don’t respond well to vaccines.Emma Wall, Senior Clinical Research Fellow at the Crick and Consultant in Infectious Diseases at UCLH, said: “The UK’s strategy to deploy stocks of older vaccines paid off last year, as both vaccines provided equal protection against the newest strain.
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