Microscopic backpacks full of drugs designed to stick to troublesome immune cells have been shown to improve the health of mice with a condition similar to multiple sclerosis in humans.
molecules that work together to boost anti-inflammatory and regulatory functions and slow down pro-inflammatory functions.
Left: A monocyte with its cell membrane stained green, nucleus blue, and backpacks in red attached. Right: Illustration of how the drug loaded backpacks are attached to monocytes. "Because of their ability to invade the CNS, infiltrate inflammatory lesions, and differentiate into macrophages, a backpack strategy allowing control over monocyte differentiation made extreme sense,""They also reduced inflammation inside the lesions and shifted the local and systemic MS-associated immune response towards a therapeutic outcome."
The scientists found the mouse models showed major improvement when treated with the monocyte cells that hiked in carrying special backpacks. After treatment, those mice only had a minor limpness in their tail, while the mice that didn't get the treatment were completely paralyzed in their back legs. The treated mice also lived longer than the untreated mice.
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