Scientists at Scripps Research have released a study which suggests their experimental HIV vaccine has the potential to be effective against multiple strains of the virus.
Researchers have announced what could be an important milestone in the elusive search to find an effective vaccine for HIV., scientists from Scripps Research and the nonprofit International AIDS Vaccine Initiative claim the AIDS vaccine they developed has been effective in initial tests conducted on rabbits. The vaccine targets multiple"sites" on the virus, which scientists believe is a critical element in developing a useful HIV vaccine.
"It's an initial proof of principle but an important one, and we're now working to optimize this vaccine design," said the study's senior author Richard Wyatt, a Scripps Research microbiology and immunology professor. The vaccine Wyatt's team are developing is designed to work by prompting the body's immune system to produce"broadly neutralizing antibodies," or bnAbs, which are capable of crippling the mechanism HIV uses to infect cells. The antibodies are produced naturally in the bodies of some HIV patients, but not in great enough numbers or early enough in the disease process to significantly alter the course of the virus.
Developing an effective vaccine for HIV has proved a difficult task for scientists, who have been working on a solution for decades.Developing an effective vaccine for HIV has proven notoriously difficult, partly due to rapid mutations of the virus. The bnAbs are capable of neutralizing multiple strains because they bind to HIV sites that remain the same despite mutation.
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