'We hope to use what we are learning from the naked mole-rat to protect ovary function later in life and prolong fertility.'
Naked mole rats appear to defy the biological rule of aging, making them somewhat enigmatic. Unlike humans and other mammals, which lose their fertility as they age, naked mole rats can reproduce throughout their very lengthy lifespans—the question of how has long baffled scientists for decades.on February 21 pinpoints unique processes that grant the rodents with what seems like eternal fertility. The discoveries could eventually point to new therapies for people.
"But to me, the most amazing thing is that they never stop having babies — they don't have a drop in fertility as they age. We want to understand how they do this," he added. Brieño-Enríquez explained three possibilities for how naked mole rats do this. Contrary to most mammals and mice, they are born with many egg cells, not as many of these cells die, or they continue to create more egg cells after birth.They found that compared to mice, naked mole-rat females contain unusually high quantities of egg cells and that the mortality rates of these cells were lower. For instance, a naked female mole rat at eight days old typically has 1.
"This is important because if we can figure out how they're able to do this, we might be able to develop new drug targets or techniques to help human health," said Brieño-Enríquez. "Even though humans are living longer, menopause still happens at the same age. We hope to use what we are learning from the naked mole-rat to protect ovary function later in life and prolong fertility."
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