Treatment regimens for non–small cell lung cancer were independent predictors of chemotherapy-triggered exacerbations.
Acute exacerbations of idiopathic interstitial pneumonia were associated with lower survival in adults with advanced lung cancer who underwent chemotherapy.Previous research suggests worse outcomes for lung cancer patients with IIP who have acute exacerbations during chemotherapy, but data on this relationship are limited.
The researchers compared overall survival among patients with lung cancer who developed acute exacerbations during first-line chemotherapy and those who did not, using a landmark analysis at 30, 60, 90, and 120 days from the start of treatment. The study population included 708 adults from 110 facilities worldwide; the mean age was 70.4 years, 645 were men, and 689 had no history of acute exacerbation.The overall median survival rate for the entire study population was 9.9 months; patients with acute exacerbations had significantly worse survival than those without exacerbations at all time points .
The incidence of acute exacerbation was greater in patients with non–small cell lung cancer than in those with small cell lung cancer . Treatment regimens specifically for non–small cell lung cancer were significant independent predictors of acute exacerbations triggered by the therapies in a multivariate analysis (odds ratio, 3.316;"If acute exacerbation occurs during first-line chemotherapy, switching to the best supportive care instead of continuing chemotherapy may be a possible option," the researchers wrote.
Nsclc Lung Cancer Lung Carcinoma Cancer Of The Lung Small Cell Lung Cancer Small-Cell Lung Cancer Oat Cell Lung Cancer SCLC Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Lung Chemotherapy Pneumonia
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