Of the cases accruing in the United States and elsewhere, most but not all were linked to inborn errors of immunity.
Receive email when new articles are published onSAN DIEGO — Approximately 10 years ago in France, high throughput screening in a series of cases suggested that vaccine-derived rubella virus was the surprising cause of persistent cutaneous granulomas, but an update at thesuggests this phenomenon is not as rare as once supposed.
Of the cases accruing in the United States and elsewhere, most but not all have been linked to inborn errors of immunity. In a 2020 CDC review, the risk of granulomas caused by compromised immunity, such as defects in T-cell function, was estimated to be in the range of 0.6%-2.5%, Dr Wanat said. Many initial cases of rubella-associated granulomas occurred on the arms, presumably where the vaccine was administered, despite long intervals between exposure and lesion growth. This interval is often measured in years.
The discovery of granulomas associated with wild type rubella infection was"shocking" based on the supposition that the rubella virus had been eliminated, but this is just one of the unexpected discoveries as the still-evolving science has traced the story of rubella-associated granulomas over the past 10 years.Shedding of the virus and risk of infection to others has been studied but so far, the risk — if it exists — is very low.
Other therapies associated with benefit in at least some patients include tumor necrosis factor inhibitors with dapsone and ribavirin. The risk of adverse events for the latter might again limit its use, Dr Wanat said.
Vaccines Rubella German Measles Primary Immunodeficiency Primary Immunodeficiencies Transplantation Of Stem Cells Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy Stem Cell Haematopoietic Stem Cell Transplant
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