The new blood test could be a valuable tool for identifying brain cancer at an early stage when symptoms first arise.
A new, affordable blood test device has been developed for early diagnosis of a deadly brain cancer : glioblastoma.
“Our technique is not specific to glioblastoma, but it was particularly appropriate to start with it because of how deadly it is and the lack of early screening tests available. Our hope is that if early detection is more feasible, then there is an increased chance of survival,” said Hsueh-Chia Chang, the Bayer Professor of Chemical and Biomolecular Engineering at Notre Dame and lead author of the study and the majority of patients diagnosed with it live only 12 to 18 months after detection.
In the glioblastoma diagnostic device, the electrokinetic sensor is used to capture and detect extracellular vesicles, which contain biomarkers associated with the disease. “Extracellular vesicles or exosomes are unique nanoparticles secreted by cells. They are big — 10 to 50 times bigger than a molecule — and they have a weak charge. Our technology was specifically designed for these nanoparticles, using their features to our advantage,” explained Chang. This biochip is said to be incredibly sensitive and selective, enabling it to differentiate between active and non-active EGFRs.
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