Our expectations of a drug's effects may have more influence than we once thought.
The Nocebo Effect: How We Think Ourselves Sick, According To Psychiatrists The following story is excerpted from The Nocebo Effect: When Words Make You Sick by Michael Bernstein, Ph.D.; Charlotte Blease Ph.D.; Cosima Locher, Ph.D.; and Walter Brown, M.D. A few months ago, I was asked by a reporter to comment on the role of the nocebo phenomenon in Havana Syndrome.
Using the open-hidden procedure described above, a pioneering study indicated that the effects of a strong narcotic such as remifentanil can be completely blocked by the suggestion that the infusion of the drug has been stopped. In one study, remifentanil was continuously infused in the participants' veins, but the participants were told that the drug was discontinued. As expected, participants experienced increased pain after being told the drug had been discontinued.
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