Eribulin is as effective as taxane when used alongside dual HER2 blockade as the initial treatment for HER2-positive, locally advanced, or metastatic breast cancer in women.
Eribulin seems to be an equally effective chemotherapy to pair with a dual HER2 blockade as taxane as first-line treatment for women with HER2-positive, locally advanced or metastatic breast cancer .
"The combination of trastuzumab, pertuzumab, and taxane is a current standard first-line therapy for recurrent or metastatic HER2-positive breast cancer," explained Dr Yamashita."However, because of taxane-induced toxicity, the development of less toxic but equally effective alternatives are needed."
For the primary endpoint, the median progression-free survival was 14 versus 12.9 months in the eribulin and taxane group, respectively . Overall,"these results suggest that eribulin is less toxic chemotherapeutic partner for dual HER2 blockade and can be used for a longer," he said.Harold Burstein, MD, PhD, a breast cancer expert at Dana-Farber Cancer Institute and professor at Harvard Medical School in Boston, described the findings as"a nice clinical pearl," because some patients do not tolerate taxane therapy.
Metastatic Breast Carcinoma Metastatic Breast Cancer MBC Mbc Advanced BC Metastatic BC Metastatic Breast Cancer (MBC) MBC - Metastatic Breast Cancer Breast Cancer Malignant Breast Neoplasm Breast Carcinoma Taxanes HER2 Positive Breast Cancer HER2+ Breast Cancer Biologic Therapy Biologics Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm
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