Monthly erenumab induced remission of nonopioid medication overuse headache safely and effectively in patients with chronic migraine, a phase 4 trial found.
Erenumab, injected monthly at 140 mg, can effectively induce remission of nonopioid medication overuse headache in patients with chronic migraine within 6 months. The treatment also significantly reduces the number of acute headache medication days .Researchers conducted a phase 4, double-blind, parallel-group, randomized, placebo-controlled study at 67 centers across North America, Europe, and Australia from October 2019 to November 2022.
The study included 584 adults with chronic migraine, at least one prevention failure, and nonopioid MOH at baseline. Participants in the nonopioid-treated group were randomly assigned to receive either 70 mg or 140 mg of erenumab or a placebo, administered subcutaneously once monthly for 24 weeks.Secondary endpoints included changes from baseline in mean monthly AHMDs and sustained remission of MOH. Adverse events were monitored..03), compared with 6.6 days in the placebo group.A total of 67% of participants reported treatment-emergent AEs in the combined erenumab group.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Migraine Headache Headache Remission Drug-Induced Headache Rebound Headache Medication Overuse Headache Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Continuing Medical Education CME Artificial Intelligence Deep Learning AI NPL Machine Learning
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