Epidermal necrolysis was associated with high rates of inhospital and post-discharge mortality in a French cohort study.
Epidermal necrolysis — which includes Stevens-Johnson syndrome , toxic EN , and SJS and TEN overlap — had an incidence of 2.6 cases per million person-years in a French study of adults.Researchers conducted a nationwide cohort study using the French Health System database that included 1221 adult patients who were hospitalized with SJS, SJS and TEN overlap, and TEN between January 2013 and December 2022.
The mortality rate at 1 year for EN was 34%. The overall inhospital mortality rate was 19%, and the post-discharge mortality rate up to 1 year was 15%. Age, diagnosis of TEN, transfer to an intensive care unit, and comorbidities such as dementia, liver disease, and cancer were associated with higher inhospital mortality. Comorbidities including cancer, liver disease, and dementia and acute kidney injury and sepsis during hospitalization were associated with higher post-discharge mortality.
Among 987 patients who survived the acute stage, 25% developed at least one new comorbidity within a year, with higher rates of ophthalmologic, mood, and respiratory disorders observed in those with TEN compared with SJS or SJS/TEN."We found that despite EN being a rare condition, it is associated with high inhospital and post-discharge mortality and a high burden of sequelae," the authors wrote.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
HCC - Hepatocellular Carcinoma Liver Cancer HCC Hepatocellular Cancer Cancer Of The Liver Liver Carcinoma Carcinoma Of The Liver France French Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Liver Disease Hepatic Impairment Social Determinants Of Health SDOH Social Determinants Of Health (SDOH) Acute Kidney Injury
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