A subgroup analysis showed that epcoritamab is effective regardless of CAR T–exposure in patients with R/R LBCL.
SAN DIEGO — Single-agent epcoritamab demonstrated deep and durable responses in chimeric antigen receptor T –naïve patients with relapsed or refractory large B-cell lymphoma in a subgroup analysis of the pivotal phase 2 Epcore NHL -1 trial.
With over 3 years of follow-up, epcoritamab monotherapy was associated with an overall response rate and complete response rate of 61% and 45%, respectively, in 96 CAR T-naïve patients, and side effects were manageable, said Karimi, of the University of Michigan, Ann Arbor, Michigan. Median progression-free survival duration was 4.3 months overall and 33.3 months among complete responders. Median overall survival was 15.4 months and was not reached in complete responders.
Fatal reactions occurred in 18 patients. Of these, nine were related to COVID-19 infection. CRS events were mostly of grade 1 or 2; 4% were of grade 3. CRS occurred most often following cycle 1 and resolved in all but two patients. ICANS occurred in seven patients, clinical tumor lysis syndrome occurred in two patients, and immunoglobulin G levels decreased by a median of about 20% after the story of treatment and remained stable over time, Karimi noted.
Biologics Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors CAR T Chimaeric Antigen Receptor T-Cell Therapy Chimaeric Antigen Receptors Chimaeric Immunoreceptors Chimaeric T-Cell Receptors Non-Hodgkin's Lymphoma Non-Hodgkin Lymphoma NHL Non-Hodgkin Lymphoma (NHL)
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