An enzyme called MICAL2 promotes tumor growth and metastasis in the most common form of pancreatic cancer, according to a new study.
Enzyme promoting tumor growth and spread in pancreatic cancer identified." ScienceDaily. ScienceDaily, 2 January 2025. <www.sciencedaily.com
Researchers discovered that treating pancreatic cancer with a common chemotherapy drug makes immunotherapy more effective. Folinic acid elevates levels of two anti-cancer immune molecules within ... Why do metastases often only appear after the original tumor has been surgically removed? Scientists have now published an explanation for this phenomenon. They were able to identify a messenger ...
Scientists have demonstrated that blocking 'cell drinking,' or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth--providing more evidence that macropinocytosis ... Scientists have shown that pancreatic cancer metastasis -- when tumor cells gain the deadly ability to migrate to new parts of the body -- can be suppressed by inhibiting a protein called Slug that ...Brain Cells Remain Healthy After a Month on the International Space Station, but Mature Faster Than Brain Cells on Earth
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LMU Researchers Decode Epigenetic Silencing of Problematic Retroviral SequencesA team led by molecular biologist Professor Gunnar Schotta from LMU's Biomedical Center has investigated how the enzyme SETDB1 silences specific DNA sections by epigenetically modifying histone proteins. This modification ensures that the DNA is densely packed, reducing the accessibility of genes. The research focuses on endogenous retroviruses (ERVs) that can affect gene activity under certain circumstances. SETDB1 prevents these sequences from becoming active by adding an epigenetic mark called H3K9me3 to the respective histones. Without SETDB1, this suppression is lacking, leading to abnormal gene expression and impaired blood cell formation.
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