Early-life and environmental exposures are more strongly linked to age at diagnosis of IBD than genetic factors.
Early-life and environmental exposure s are more strongly linked to age at diagnosis of inflammatory bowel disease than genetic factors, a large study of IBD patients reported.that environment influences the onset of both ulcerative colitis and Crohn 's disease , and exposures typical in Western society lower the age of diagnosis. These factors include birth in a developed nation, delivery by C-section, and more bathrooms in the home, according to Oriana M.
"Additionally, very few studies have examined the contribution of genetics or environmental factors in Hispanic individuals, and our study examined the contribution of these factors in this understudied population," she added. . In genetically predisposed individuals, environmental culprits in developed countries are thought to negatively shape the intestinal microbiome's composition into a less tolerant and more proinflammatory state, the authors noted. the over-sanitization of the developed-world life is partly to blame.
Early plastic water bottle use — which has been linked to inflammatory microplastics in the intestines — and homes with more than one bathroom were also associated with younger age at diagnosis. Susceptibility to environmental exposures was similar in Hispanic and NHW patients. "This is an interesting and important study," commented Ashwin Ananthakrishnan, MBBS, MPH, AGAF, director of the Crohn's and Colitis Center at Massachusetts General Hospital in Boston, who was not involved in the study."There are few environmental risk factor studies looking at non-White populations and to that end, this is a very large and well-done analysis looking at environmental factors among Hispanic patients with IBD.
IBD - Inflammatory Bowel Disease IBD Genetics Genomics Genomic Medicine Environmental Exposure Pollutant Pollution Toxicology Toxicity Poisoning Toxins Birth Colitis Crohn's Disease Crohn Disease Regional Enteritis Crohn Crohn’S Ulcerative Colitis Ulcerative Colitis (UC) UC - Ulcerative Colitis Pregnancy Pregnant Antibiotics Autoimmune Disease Blood
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