How do odorant receptors in the human nose recognize a wide variety of scent molecules? The structures of engineered versions of these receptors finally provide much-needed answers to this fundamental question. The structures of engineered odorant receptors.
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser . In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.Humans can distinguish a multitude of odorant molecules that have a wide variety of chemical structures.
To understand how distinct smells are discriminated between, we need to understand how odorant receptors in the olfactory neurons of the noseinteract with the various odorants. However, efforts to determine 3D structures of these receptors using cryogenic electron microscopy have been hampered by the fact that these receptors are poorly expressed in model cell lines.
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