Results from the first-in-human trial of a new mRNA-based cancer vaccine are promising, as are early results from two other trials presented at ESMO.
"Most importantly, the strong de novo T-cell responses seen in a significant number of patients reflect the vaccine's ability to break through immune tolerance to the tumor and generate a new immune response," said Tabatabai, who presented the findings here at theMGMT-unmethylated glioblastoma has a poor prognosis, with a median overall survival of roughly 12 months following surgery and chemoradiation withmRNA vaccines have been shown to induce CD4+ and CD8+ T cell responses...
Patients received four dose levels of the vaccine — 12 µg in three patients, 25 µg in three patients, 50 µg in three patients, or 100 µg in seven patients — as seven intramuscular injections within 10 weeks, and optimal maintenance vaccinations at the investigator's discretion. headache Most notably, within the group of patients who responded, 84% of immune responses were generated de novo by the CVGBM vaccine, inducing T-cell activity in patients who had no pre-existing T-cell activity against the encoded antigens.
Bart Neyns, MD, PhD, with Vrije Universiteit Brussel, Belgium, reported that intracranial administration of autologous myeloid dendritic cells in combination withYulun Huang, MD, with the Fourth Affiliated Hospital of Soochow University, Suzhou, China reported that intrathecal injection of allogeneic CAR-γδT cells targeting B7H3 for the treatment of recurrent high-grade glioblastoma was safe and led to an objective response rate of 43% and disease control rate of 100%, and a median...
Vaccine Vaccines Malignant Head And Neck Neoplasm Head And Neck Cancer Head And Neck Cancer (HNC) Cancer Vaccine Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors
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