Initiating empagliflozin vs a DPP-4 inhibitor may slow the progression of diabetic retinopathy in patients with type 2 diabetes and a history of nonproliferative diabetic retinopathy, a US-based cohort study found.
Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, did not reduce the risk for incident nonproliferative diabetic retinopathy compared with dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes , but the drug did reduce the risk for its progression by 22% in patients with existing retinopathy.
The 7831 pairs of patients with diabetes who were included in the diabetic retinopathy progression cohort were required to have a history of nonproliferative diabetic retinopathy. The initiation of empagliflozin was associated with a lower risk for progression of diabetic retinopathy compared with initiation of a DPP-4 inhibitor .
“The weaker glucose-lowering effect of DPP-4 inhibitors may have meant that more people in this group were subsequently changed to what was likely a third- or fourth-line glucose-lowering drug. Insulin and glucagon-like peptide 1 receptor agonists are often used in this role, are the most potent glucose-lowering drugs, and have both been associated with the early worsening of DR that can occur after rapid improvement in blood glucose control,” they wrote.
Retinopathy Microvascular Complications Of Diabetes Retinal Disease Proliferative Diabetic Retinopathy Hypertension Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Blood Dpp-4 Inhibitors Dipeptidyl Peptidase-4 Inhibitors Grant Hospitals SGLT2 Inhibitors Sodium-Glucose Transporter-2 Inhibitors
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